Anti-Inflammatory Effects of Progesterone on Human Microglia via TLR4/NLRP3 Pathway Modulation: Relevance to Drug-Resistant Epilepsy.

Pharmaceuticals (Basel) · 2026 · PMC13306037 · PMID 42356537

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did not reach statistical significanceno p-value reported

As shown in Figure 3 , LPS induced an increase in TLR4 mRNA levels ( p < 0.0001; Tukey’s t -test), whereas P4 had a tendency to counteract LPS effects, although the differences did not reach statistical significance.

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