Effects of Caloric Restriction on DNA Damage: A Comparison of Very Low-Calorie and Standard Reduced-Calorie Diets in Obesity-Non-Randomised, Quasi-Experimental Clinical Intervention Study.

Although baseline fasting glucose levels were higher in the VLCD group than in the SRD control group, the subsequent post-dietary decreases did not reach statistical significance within either individual cohort ( p = 0.517) for VLCD and ( p = 0.675) for SRD.

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Crucially, the VLCD intervention was associated with a highly significant within-group reduction in parameters of permanent chromosomal damage, effectively halving the frequencies of micronuclei and nuclear buds, independent of baseline variations, in adjusted multivariate regression models.

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