Genetic variation associated with depression in Latin American populations: a systematic review of single-nucleotide variants.

Front Psychiatry · 2026 · PMC13307694 · PMID 42368811

Europe PMC DOI

hedged sentences

0.0610

closest p · 1.2× alpha

0.0610

boldest claim

The sentences

a trend toward significancep = 0.061so close (0.05 < p ≤ 0.1)

In contrast, the Latino subgroup showed a trend toward significance (p = 0.061; OR = 1.48; 95% CI = 0.98–2.24), with differences in allele frequencies between non-remitters (MAF = 0.344) compared to remitters (MAF = 0.429).

also in 2,500 other papers

showed a trendp = 0.061so close (0.05 < p ≤ 0.1)

In contrast, the Latino subgroup showed a trend toward significance (p = 0.061; OR = 1.48; 95% CI = 0.98–2.24), with differences in allele frequencies between non-remitters (MAF = 0.344) compared to remitters (MAF = 0.429).

also in 33,237 other papers

a suggestive trendno p-value reported

When these findings are considered alongside results from the multi-ethnic STAR*D cohort, also including participants with MDD, in which no significant associations were observed in Caucasian or African American participants, but a suggestive trend was present in Latinos ( 37 ), the overall pattern is consistent with a population-specific modulation of antidepressant response rather than a universal pharmacogenetic effect.

also in 137 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.