Neuronal safety of Kv11.1 blockers: Patch-clamp and in vitro evaluation with physiologically based pharmacokinetic (PBPK) modeling.

Toxicol Rep · 2026 · PMC13308230 · PMID 42369237

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did not reach statistical significanceno p-value reported

MTT showed no changes at low doses, and Alamar Blue exhibited consistent but variable dose-related declines, indicating modest redox shifts that did not reach statistical significance. 3.4 Blood Brain Barrier (BBB) Permeability In vitro experiments assessed drug effects by direct application to the cells, whereas in vivo neuronal exposure depends on each compound’s ability to cross the blood-brain barrier.

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