Plasma p-tau217 best captures early longitudinal cognitive changes in subjective cognitive decline compared with p-tau181 and NfL.

J Neurol · 2026 · PMC13309395 · PMID 42360503

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closest p · 1.1× alpha

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boldest claim

The sentences

showed a trendp = 0.055so close (0.05 < p ≤ 0.1)

Compared with the negative group, the p-tau217-positive group showed a significantly different longitudinal trajectory (β − 4.28, SE 1.63, p = 0.012), while the gray-zone group showed a trend toward a different trajectory (β − 2.79, SE 1.41, p = 0.055).

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