Role of the stromal and immune microenvironment in intrahepatic cholangiocarcinoma.

60 In comparison, tumours with IDH1 mutations showed a trend toward more fibroblasts and were characterised by a closer proximity of tumour cells to CD4 + T cells, as well as between macrophages and multiple structural components of the TME, compared with other subtypes. 60 While these findings require further investigation, conflicting data exist regarding whether IDH1-mutated iCCAs are associated with a non-inflamed 37 , 61 or inflamed immunophenotype 57 ( Table 2 ).

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