An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella infection.

Nat Immunol · 2026 · PMC13310766 · PMID 42120792

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showed a trendno p-value reported

In contrast to PYCARD -proficient organoids, which showed a trend toward increased Paneth lineage upon infection ( P adj = 0.0782), PYCARD −/− clones failed to show a comparable upregulation (Fig. 4l ).

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