Proteomic and Clinical Characterization of Active vs. Quiescent Pterygium With Elevated Thrombospondin-1.

Analysis of MSigDB Hallmark gene sets further identified biologically pertinent, albeit nominally significant, coordinated changes: the epithelial–mesenchymal transition signature was positively enriched, whereas the DNA repair pathway was negatively enriched, suggesting a concomitant activation of tissue-remodeling programs and a potential decline in genomic maintenance ( Fig. 3 B).

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