Endothelial cell glycogen synthase kinase 3β promotes lipotoxic endotheliopathy and liver inflammation in MASH.

Although the GSK3 inhibitor LY2090314 (LY) is primarily an ATP-competitive inhibitor, it showed a decreasing trend in pGSK3α/β, which may be attributed to the suppression of GSK3 autophosphorylation ( 24 ).

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Three B cell clusters (Cluster 2, 5, and 6) showed an increasing trend in Gsk3β ΔEnd mice ( Supplemental Figure 5 , M–O).

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While this population represented a small fraction of total IHLs, we observed that it was enriched in MASH mouse livers and showed a downward trend in Gsk3β ΔEnd mice, although it did not reach statistical significance.

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