NOTCH1 acts as a tumor suppressor that induces early differentiation in head and neck cancer.

JCI Insight · 2026 · PMC13313506 · PMID 41989846

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showed a trendno p-value reported

NOTCH pathway scores showed a trend toward worse survival in HPV + TCGA HNSCC patients (not shown), possibly because HPV oncogenes interfere with differentiation programs, reducing reliability of downstream target-based tumor separation.

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