Low-density neutrophil heterogeneity and spleen tyrosine kinase as therapeutic targets in sepsis.

We further assessed the total expression (MFI) of each of these features across SYK + WBNs to SYK – WBNs, SYK + LDNs to SYK – LDNs, and SYK + WBNs to SYK + LDNs and found that differential expression produced similar results when comparing percentages ( Figure 6, A–C ), except for higher CD15 in SYK + WBNs versus SYK – WBNs, which did not reach statistical significance ( Supplemental Figure 9, A–C ).

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