Hypothalamic insulin resistance in type 2 diabetes is localized to the posterior hypothalamus.

JCI Insight · 2026 · PMC13313559 · PMID 42258747

Europe PMC DOI

hedged sentence

0.0570

closest p · 1.1× alpha

0.0570

boldest claim

The sentences

did not reach statistical significanceP = 0.057so close (0.05 < p ≤ 0.1)

A significant main effect of time was detected for serum insulin, C-peptide, and FFA concentrations (all P < 0.001), whereas the effect of time on plasma glucose did not reach statistical significance ( P = 0.057).

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