Effects of <i>Citrus unshiu</i> Intake on Serum Brain-Derived Neurotrophic Factor Levels and Mood States: A Pilot Randomized Controlled Trial.

In our study, although the observed increase in serum BDNF concentrations from Week 4 to Week 8 did not reach statistical significance, the mean value showed a tendency to increase by approximately 1.41 ng/mL (11.4%) in the CU group.

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Serum BDNF levels in the NCU group showed a decreasing trend from Week 0 to Week 8, which is consistent with previous findings indicating seasonal variation, with BDNF levels decreasing during the autumn-to-winter period ( Molendijk et al., 2012 ).

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