Proline-directed phosphorylation and prolyl isomerization oppose each other to regulate PSD-95 ubiquitination and excitatory synaptic plasticity.

Front Mol Neurosci · 2026 · PMC13314775 · PMID 42381736

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0.1600

closest p · 3.2× alpha

0.1600

boldest claim

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did not reach statistical significancep = 0.16not close (p > 0.1)

K63A: T = 0, 1.00 ± 0.17; T = 10, 0.70 ± 0.08; T = 20, 0.61 ± 0.08; T = 30 0.74 ± 0.15); however, this difference did not reach statistical significance (Two-way ANOVA Genotype: F(1, 40) = 2.01, p = 0.16; Time: F(3, 40) = 0.16, p = 0.93; Interaction: F(3, 40) = 1.13, p = 0.35).

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