Sex-based differences in tolerability of developmental antibody-drug conjugates (ADCs) in non-small-cell lung cancer (NSCLC).

ESMO Open · 2026 · PMC13315325 · PMID 42330841

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

a nonsignificant trendP = 0.08so close (0.05 < p ≤ 0.1)

Gastrointestinal (GI) were the most common TRAEs overall (32.6%), with a nonsignificant trend towards higher rates in women (40.6% versus 25.0%; P = 0.08).

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did not reach statistical significanceno p-value reported

Conversely, men in our study appeared to have a slightly higher incidence of ILD, consistent with prior reports with other treatment regimens, 13 although this trend did not reach statistical significance.

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