Interim assessment by circulating tumor DNA in primary mediastinal large B-cell lymphoma: a multicenter LYSA study.

The bulky disease variable could not be included due to nonconvergence of the Cox model, and although TMTV could be considered as a proxy, it did not reach statistical significance in univariate analysis and, in addition, its inclusion would have led to the exclusion of 10 additional patients due to missing data, thereby reducing statistical power without providing consistent independent prognostic information.

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