A Retrospective Evaluation of Phenobarbital and Benzodiazepine Monotherapy and Combined Therapy in the Treatment of Alcohol Withdrawal Syndrome in a Canadian Emergency Department.

Cureus · 2026 · PMC13318263 · PMID 42382870

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did not reach statistical significanceno p-value reported

There was also a trend toward lower rates of return presentation to the ED in patients who received phenobarbital (6%) compared to benzodiazepines (11%), but this did not reach statistical significance.

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