A transcriptome-defined TAM-rich phenotype identifies a macrophage-enriched, hypoxia-linked immune contexture in glioblastoma: multi-cohort transcriptomic validation and local histopathological correlation.

Front Immunol · 2026 · PMC13318709 · PMID 42389535

Europe PMC DOI

hedged sentence

0.1370

closest p · 2.7× alpha

0.1370

boldest claim

The sentences

did not reach statistical significanceP = 0.137not close (p > 0.1)

Within-cohort z-score standardized continuous-score Cox models showed modest positive associations in CGGA_693 (HR 1.14, 95% CI 1.00-1.31, P = 0.048) and CGGA_325 (HR 1.21, 95% CI 1.01-1.46, P = 0.044), whereas the association did not reach statistical significance in TCGA (HR 1.10, 95% CI 0.97-1.26, P = 0.137).

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