Repurposing loratadine to induce ferroptosis and overcome multidrug resistance: preclinical evidence in KB-V-1 cells.

As a supplementary measure, area under the tumor growth curve (AUC) was calculated using the trapezoidal method in GraphPad Prism; while AUC values trended in the expected direction, the differences did not reach statistical significance (p ≥ 0.05), likely reflecting dilution of the integrated area by the pre-divergence period when all groups had comparable tumor volumes early in the study ( Supplementary Figure 2 ).

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