Short-term exposure to CO and NO<sub>2</sub> and Kawasaki disease onset in a cold region of China: a distributed lag non-linear time-series study.

Additional sensitivity analyses using more conventional exposure contrasts, including the 75th versus 50th percentile and the 90th versus 50th percentile, showed exposure-response trends generally consistent with the main analysis, although the estimates did not reach statistical significance ( Supplementary Figures S7, S7 ). 4 Discussion This study collected KD hospitalization records from two major medical centers in Heilongjiang Province between 2015 and 2022, and for the first time in a high-latitude cold region, applied a distributed lag non-linear model to systematically evaluate the associations between six major ambient air pollutants and KD onset in children.

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