Twin growth discordance trajectories and fetal growth velocity for predicting adverse neonatal outcomes: a multicenter cohort study.

The overall interaction between FGVB and trajectory class did not reach statistical significance in the development cohort ( p = 0.059) nor in the validation cohort ( p = 0.742; Supplementary Table S7 ); nevertheless, the specific interaction term for FGVB × Low rapid increasing trajectory was significant in the development cohort (OR 1.35, 95% CI 1.08–1.69, p = 0.008; Supplementary Table S7 ; Figure 5A ; Supplementary Figure S2 ), promoting exploratory trajectory-stratified analyses to evaluate the discriminatory performance of FGVB within each trajectory class.

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