Elevated sclerostin levels in cerebrospinal fluid are associated with cognitive impairment in the Alzheimer's disease continuum.

The association of CSF sclerostin with age and education showed a positive correlation with age ( r = 0.243, p = 0.0032) and a negative trend with education ( r = −0.148, p = 0.075). 3.3 Correlation between CSF sclerostin and cognition For the screening tests (Figure S2 in supporting information), the statistical analyses evidenced negative correlations between CSF sclerostin levels and MMSE ( r = −0.304; p = 0.0003), FAB ( r = −0.358; p < 0.0001), and CDT scores ( r = −0.257; p = 0.004), indicating the association between higher CSF sclerostin levels and worse global cognitive measures.

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In women, all significant associations observed in the overall cohort were confirmed, except for ROCF ( r = −0.333; p = 0.063) and TMT‐B ( r = 0.263; p = 0.097), which showed a negative and a positive trend, respectively.

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