Circulating tRF-Gly-GCC as a biomarker for colorectal cancer and Crohn's disease activity.

A Jonckheere–Terpstra test for ordered alternatives confirmed a highly significant monotonic increase across the four pre-specified ordered groups (standardized J–T statistic z = 7.896, p < 0.001).

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tRF-Gly-GCC demonstrated the highest diagnostic accuracy for distinguishing active from inactive Crohn’s disease (AUC = 0.910, 95% CI 0.765–1.000, p < 0.001), with 90.0% sensitivity (95% CI 68.3–98.8) and 90.0% specificity (95% CI 62.1–96.8), whereas fecal calprotectin did not reach statistical significance (AUC = 0.629, p = 0.164) (Table 3 ; Fig. 3 c).

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