Graph theory reveals functional connectome disruptions in adolescent major depressive disorder with childhood trauma.

Comparing MDD responders and non-responders, nominally significant group by time interactions were observed for the nodal efficiency of left amygdala ( χ 2 = 3.394, p = 0.047; Cohen’s d = 0.585; 95% CI, 0.01–1.16) and λ ( χ 2 = 6.652, p = 0.009; Cohen’s d = −0.680; 95% CI, −1.19. to −0.16) (Supplementary Fig. 2a, b ).

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