Barely Significant
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Higher cardiovascular risk observed with beta-blockers in CKD patients without prior cardiovascular disease.

Clin Kidney J · 2026 · PMC13320235 · PMID 42389200

Europe PMCDOI
2
hedged sentences
0.0500
closest p · 1.0× alpha
0.0500
boldest claim

The sentences

borderline significanceP = 0.05actually significant
Similar trends were observed for each MACE component, whereas CV death showed a weaker separation, with borderline significance ( P = 0.05) ( Fig.

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did not reach statistical significanceno p-value reported
For ischemic stroke and non-fatal MI, carvedilol and other BBs showed associations, whereas nebivolol did not reach statistical significance (stroke: HR, 1.23; 95% CI, 0.99–1.54; MI: HR, 1.15; 95% CI, 0.78–1.70).

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