Epidemiology and Clinical Characteristics of Pediatric Acute Postinfectious Glomerulonephritis in Montenegro: A Nationwide Retrospective Study.

Although these associations did not reach statistical significance, the observed trend is biologically plausible and aligns with the immune-mediated pathogenesis of APIGN, in which complement activation and deposition at the glomerular basement membrane play a central role. 13 , 14 A small proportion of patients had normal C3 levels at presentation, confirming that normal complement levels do not exclude the diagnosis of APIGN. 5 , 13 Collectively, these findings support the potential utility of serum C3 as a marker of disease severity and highlight the need for prospective studies to further evaluate its prognostic value in pediatric APIGN.

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