Causal relationships between irritable bowel syndrome and brain functional networks: A Mendelian randomization study.

For statistical significance, we adopted a tiered threshold approach: (1) the P value of IVW method less than 0.05 was considered to be nominally significant results; (2) the P value was further corrected using the Bonferroni method and was set as 1.31×10 −4 (0.05/191/2, where 191 is the number of rsfMRI phenotypes, 2 represents forward and reverse MR analyses) for significant results.

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