Reduced levels of ITGB1 cause activation of p38MAPK-ERK-LYN axis of BCR::ABL1 signaling despite inactivation of the oncoprotein by imatinib - novel resistance mechanism in blast crisis of chronic myeloid leukemia unraveled.

Cell Commun Signal · 2026 · PMC13321628 · PMID 42093005

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showed a trendno p-value reported

6 A and B) showed a trend towards increase in imatinib-resistant patients as compared to the responders.

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