Pharmacological inhibition of G protein-coupled receptor kinase 2 (GRK2) by paroxetine attenuates acetaminophen-induced hepatotoxicity.

Under APAP (10 mM)-induced hepatotoxic conditions, paroxetine exposure led to a dose-dependent and statistically significant reduction in ALT levels in AML12 cells, whereas Huh-7 cells showed a similar decreasing trend that did not reach statistical significance ( Fig. 1D ). siGRK2 transfection also resulted in significant reductions in ALT levels at both intermediate and high siRNA doses in AML12 and Huh-7 cells.

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