Development and validation of a uric acid-inflammation-metabolism score for predicting osteoarthritis risk: evidence from NHANES 2007-2018 and an external Chinese cohort.

Front Endocrinol (Lausanne) · 2026 · PMC13322868 · PMID 42395189

Europe PMC DOI

hedged sentences

0.6610

closest p · 13.2× alpha

0.6610

boldest claim

The sentences

did not reach statistical significanceP = 0.661not close (p > 0.1)

Diabetes stratification: An enhanced association trend between UIM score and OA was observed in diabetic patients (OR = 2.77 vs 2.59), though the interaction P value did not reach statistical significance (interaction P = 0.661). eGFR stratification: The effect size in the eGFR < 60 mL/min/1.73 m2 group was lower than in the eGFR ≥ 60 group (OR = 2.13 vs 2.77), with interaction P = 0.170, not reaching significance.

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highly significantno p-value reported

Although the association attenuated with progressive adjustment for confounding factors, it remained highly significant: Model 2 (adjusted for age and sex): Q4 vs Q1 OR = 2.50 (95% CI: 1.39-4.49); Model 3 (further adjusted for lifestyle factors): Q4 vs Q1 OR = 2.71 (95% CI: 1.51-4.87); Model 4 (fully adjusted): Q4 vs Q1 OR = 2.63 (95% CI: 1.47-4.72, P < 0.001).

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