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Machine learning-driven identification and immunohistochemical validation of an integrated immune-inflammatory phenotype for disease-free survival stratification in breast cancer.

Front Immunol · 2026 · PMC13323226 · PMID 42396465

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Pathological T2 stage was also independently associated with worse DFS compared with T1 disease (HR 1.93, 95% CI 1.11–3.35, p = 0.020), whereas T3–4 disease did not reach statistical significance, likely reflecting the very small number of cases in this subgroup.

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