The efficacy and safety of high versus low doses of intravenous intraoperative tranexamic acid during spinal fusion in patients with adolescent idiopathic scoliosis: a network meta-analysis of randomized controlled trials.

We found that both high and low dose TXA regimens showed modest lower overall blood loss compared with no TXA—by roughly 200–300 mL on average—though the degree of reduction was not uniform across all metrics and did not reach statistical significance.

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