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Role of Preoperative Tapentadol in Reduction of Peri-operative Analgesics Requirements After Breast Conservative Surgery in Cancer Patients: A Randomized Controlled Trial.

J Cancer Allied Spec · 2026 · PMC13323604 · PMID 42394994

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However, reductions in postoperative opioid use and prolongation of time to rescue analgesia did not reach statistical significance and should be interpreted with caution.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.