Barely Significant
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The dynamic evolution of circulating tumor cells during glecirasib treatment predicts survival and resistance in gastrointestinal tumors with KRAS<sup>G12C</sup> mutation.

Hum Cell · 2026 · PMC13323780 · PMID 42384131

Europe PMCDOI
3
hedged sentences
0.0860
closest p · 1.7× alpha
0.0860
boldest claim

The sentences

showed a trendp = 0.086so close (0.05 < p ≤ 0.1)
E/M-CTC ≤ 1 showed a trend toward improved OS ( p = 0.086).

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a decreasing trendno p-value reported
In contrast, long-term responders (patient-2, patient-12, patient-14, patient-17) showed dynamics dominated by M-CTCs changes, with a decreasing trend in M-CTCs proportion during the treatment response phase and an increase upon disease progression (Fig. 3 B).

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a favorable trendno p-value reported
Moreover, as compared to patients with higher E/M-CTCs levels, those with E/M-CTCs ≤ 1 exhibited a favorable trend toward improved overall survival (OS), though not statistically significant ( p = 0.086) (Fig. 4 D).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.