Evolution of Hsp90 targeting: From stress biology to clinical translation.

In vivo, systemic ganetespib significantly reduced PD-L1 surface expression on live MC38 tumor cells, and a trend toward increased intratumoral CD69+CD8+ T-cell activation was observed, though this did not reach statistical significance. 233 The discovery of PD-L1 as a direct Hsp90 client protein by Eisa and colleagues provides a further mechanistic basis for this axis.

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