Association between adverse childhood experiences and cardiovascular disease risk in cardiovascular kidney metabolic syndrome stages 0 to 3.

Sci Rep · 2026 · PMC13324594 · PMID 42062379

Europe PMC DOI

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failed to reach statistical significanceno p-value reported

Conversely, social adversities failed to reach statistical significance across all evaluated model specifications.

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a decreasing trendno p-value reported

Specifically, the mean BMI was highest in the low ACE group (23.8 ± 4.1) and showed a decreasing trend with higher ACE exposure.

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highly significantno p-value reported

When examining ACE subtypes, intrafamilial adversities demonstrated a highly significant association with incident cardiovascular disease (HR = 1.08 per point, 95% CI: 1.04 to 1.13).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.