Distinct molecular and clinical aggressiveness in very early-onset metastatic colorectal cancer: survival and genomic divergence between patients aged 30-39 versus 40-49 years.

ESMO Open · 2026 · PMC13325296 · PMID 42349246

Europe PMC DOI

hedged sentences

0.0860

closest p · 1.7× alpha

0.0860

boldest claim

The sentences

did not reach statistical significanceP = 0.086so close (0.05 < p ≤ 0.1)

Patients aged 30-39 years were numerically more likely to receive triplet-based regimens compared with those aged 40-49 years (50.8% versus 38.7%), although this difference did not reach statistical significance ( P = 0.086).

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a nonsignificant trendno p-value reported

Collapsed pairwise comparisons showed a nonsignificant trend towards a higher prevalence of right-sided primary tumours in patients aged 30-39 years compared with those aged 40-49 years (43.1% versus 30.7%; Fisher’s exact P = 0.071), whereas no differences were observed for left-sided disease or rectal primaries.

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