TGFβ activity stabilizes ACC1 to increase de novo lipogenesis in metabolic liver disease.

4 N-P), although this decrease did not reach statistical significance, suggesting that additional NPC populations contribute to the liver LTBP3/TGFβ pool. 2.5 TGFβ activity regulates hepatocyte de novo lipogenesis We next turned our attention to how LTBP3/TGFβ action on TGFβR/SMAD4+ hepatocytes affected physiologic processes that regulate hepatocyte TG content.

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