ASCL2-mediated macrophage-myofibroblast transition generates immunosuppressive CAF_7 in NSCLC bone metastases.

J Exp Clin Cancer Res · 2026 · PMC13325787 · PMID 42152025

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did not reach statistical significanceno p-value reported

While siASCL2 monotherapy (siASCL2 + IgG) significantly suppressed tumor growth versus controls (siNC + IgG), PD-1 blockade alone (siNC + αPD-1) exerted a limited effect that did not reach statistical significance.

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