In line with this, catalytic efficiencies for C1 to C3 aldehydes did not show a clear trend depending on substrate size and are quite similar in these enzymes, showing maximally a 10‐fold difference [ 26 ].
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C2α-carbanion-protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2-hydroxyacyl-CoA lyase.
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