Comprehensive Framework of Heart Failure with Preserved Ejection Fraction Management for Hospitalists: A Scoping Review.

J Brown Hosp Med · 2026 · PMC13330571 · PMID 42405364

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did not reach statistical significanceno p-value reported

Although the primary composite endpoint of total HF hospitalizations and cardiovascular death was numerically lower with sacubitril/valsartan vs valsartan (HR: 0.87; 95% CI: 0.75-1.01), it did not reach statistical significance; however, sacubitril/valsartan is recommended for its comprehensive cardiovascular effects. 37 ARBs serve as a viable alternative when ARNIs are contraindicated or not feasible.

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