Final Infarct Volume as a Surrogate End Point in Anterior Circulation ICAS-LVO Stroke: Post Hoc Secondary Analysis of RESCUE-ICAS.

The direct effect was not significant (ADE: β =−0.229 [95% CI −0.643 to 0.205]; P =0.276), and the total effect did not reach statistical significance ( β =−0.354 [95% CI, −0.766 to 0.111]; P =0.120), with an estimated 35% proportion mediated ( P =0.148).

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