Precision oncology in gastric cancer: navigating molecular subtypes, therapeutic targets, and future horizons.

Cell Oncol (Dordr) · 2026 · PMC13332087 · PMID 42105153

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failed to reach statistical significanceno p-value reported

For instance, the JACOB trial, which evaluated the addition of dual HER2 blockade (pertuzumab) to trastuzumab and chemotherapy in the first-line setting, narrowly failed to reach statistical significance for its primary OS endpoint, despite a numerical improvement.

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