Genetic Associations Between Premature Ovarian Insufficiency and Bone Health Traits: A Bidirectional Two-Sample Mendelian Randomization Study.

Int J Womens Health · 2026 · PMC13332761 · PMID 42403512

Europe PMC DOI

hedged sentence

0.0390

closest p · 0.8× alpha

0.0390

boldest claim

The sentences

nominally significantP = 0.039actually significant

Reverse MR suggested nominally significant associations: higher genetically predicted heel BMD was associated with lower POI risk ( OR = 0.792, 95% CI : 0.635–0.988, P = 0.039), while genetic susceptibility to wrist fracture ( OR = 1.44, 95% CI : 1.038–1.986, P =0.025) and pelvic fracture ( OR =1.177, 95% CI :1.056–1.312, P =0.003) were associated with increased POI risk.

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