SERPINA3 as a Secreted-Protein Biomarker Associated with Poor Prognosis and T-Cell Dysfunction in Non-small Cell Lung Cancer.

In an exploratory sensitivity analysis using tertile-based grouping of BALF SERPINA3 , the overall patterns of OS and PFS were broadly similar to those observed in the primary median-based analysis, although the differences did not reach statistical significance ( Supplementary Figure S3 ).

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In the BALF registry, higher BALF—but not plasma— SERPINA3 independently predicted shorter PFS, with a nonsignificant trend toward OS after adjustment.

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