Genetic variants underpinning lung function decline in the Lifelines general population cohort study.

In the CHARGE-SpiroMeta cohort, rs4820911 and rs11030451 were nominally significant but both with an effect in the opposite direction of Lifelines (rs4820911:G, β ( se ): −14.3 (7.2) mL·y −1 , p=0.047; and rs11030451:C, β ( se ): 7.4 (3.6) mL·y −1 , p=0.04) ( supplementary table S2 ).

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