Combination of Voluntary Wheel Running and Oral Intake of Lactate Improves Object and Spatial Recognition Memory in Association With Hippocampal Insulin-Like Growth Factor-1 in Mice.

Although the expression levels of MCT2 proteins in the EX and EX+L50 groups showed a slight upward trend compared to the control, the differences did not reach statistical significance (Figure 4C ). 3.5 L50 Combined With Exercise Significantly Increases the Expression of Markers of Neural and Synaptic Activity but Does Not Affect BDNF Levels in the Hippocampus of Mice Given the significant improvement in cognitive function in the exercise + L50 group, we wondered why the combination of L50 with exercise improved cognitive function while L50 or exercise alone did not.

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