A Biomimetic Dual-Targeting Nano-APA-Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy.

Adv Sci (Weinh) · 2026 · PMC13336823 · PMID 42294590

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showed a trendno p-value reported

Genes with shortened 3'UTR generally showed a trend toward increased expression (Figure 6C ).

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highly significantno p-value reported

The primary goal of this study was to engineer a robust delivery vehicle to enhance the targeted in vivo application of CRISPR therapeutics, relying on the highly significant, system‐exclusive knockdown of NUDT21 (via RNA‐seq) as functional proof of efficacy.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.