Targeting the ATX-LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways.

Further correlation analyses in the TCGA and E‐MTAB‐1980 cohorts revealed that only PLA2G4C and ENPP2 exhibited consistent positive associations with PD‐L1 expression across both cohorts (Figure S1A,B ) (though ENPP2 did not reach statistical significance in the E‐MTAB cohort).

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