Nuclear genetic modulation of tissue-specific mitochondrial RNA processing contributes to common disease risk.

Nat Commun · 2026 · PMC13338043 · PMID 42062290

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP = 3.2 × 10 –103actually significant

Among these, MTND2 had highly significant associations across HDL cholesterol, Apolipoprotein A1, LDL and Triglycerides (lowest P = 3.2 × 10 –103 ).

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nominally significantno p-value reported

Of the 1200 possible variant and tissue combinations (25 variants x 48 tissues), approximately half showed nominally significant associations (Supplementary Data 4 ).

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